There are the beautiful Baroque towns like Modica, Ragusa Ibla, Scicli and Ispica:
Inspector Montalbano film locations;
An abundance of lovely beaches;
Local food and earth trails for wine, olives, olive oil, cheese, chocolate and ceramics;
Wonderful nature reserves (Vendicari, Irminio river);
Fascinating towns that were at the centre of the tuna fishing industry of yesteryear; and Amazing Magna Grecia historical sites like Siracusa and Kamarina.
You can also be in Malta in 90 minutes by taking the Catamaran from the nearby Port.